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Isotretinoin: Indication, Dosage, Side Effect, Precaution | MIMS Malaysia

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  Try to take it at the same time each day. The dose of this medicine will be decided by your doctor. Your doctor will advise you on the treatment timeframe. At Lazada Malaysia, you can find your outfit requirements for all your special occasions. Need the perfect gown for prom or a special dinner event find it. Safety and efficacy of fixed-dose 10 mg daily isotretinoin treatment for acne vulgaris in Malaysia. J Cosmet Dermatol. Sep;16(3) doi. ❿  


Isotretinoin di malaysia.Isotretinoin



  i) Symptomatic treatment of chronic stable angina pectoris in coronary artery disease adults with normal sinus rhythm and heart rate ≥ 70 bpm. Ivabradine is. Roaccutane® (isotretinoin) Email: localhost@localhost product details or information otherwise not accessible or valid in your country. Please refer to the Malaysia prescribing information. Generic Medicine Info. Indications and Dosage. Oral Acne. Adult: In severe cases such as nodular.     ❾-50%}

 

Isotretinoin - Oral Patient Medicine Information | MIMS Malaysia - MeSH terms



    Indications and Dosage Oral Acne Adult: In severe cases such as nodular or conglobate acne, or acne at risk of permanent scarring, which are resistant to standard therapy including systemic antibiotics and topical therapy: As conventional cap: Initially, 0. Delay therapy in patients with sunburn until resolved. How effective is this drug? Why do I need this medicine? Do not donate blood while taking this medicine and for 1 month after treatment as this medicine may cause harm to the baby if a pregnant patient receives your blood. The dose of this medicine will be decided by your doctor. It reduces sebum production reflecting a decrease in the size of sebaceous gland and inhibition of its differentiation.

Als u overgevoelig bent, dan merkt u dat in de eerste dagen. Daarna kunt u de gel 2 keer per dag aanbrengen, 's ochtends en 's avonds.

Heeft u een donkere of gevoelige huid. Gebruik het dan in het begin om de dag.

Isotretinoin - oral. Patient Medicine Information. Why do I need this medicine? Isotretinoin is used to treat severe forms of acne pimple.

It is given to those who have failed previous therapy such as antibiotics or topical treatments. How do I take this medicine? Take Isotretinoin exactly as directed by your doctor or according to the instructions on the label. Do not take more or less than instructed by your doctor. Ask your doctor or pharmacist about whether you should take this medicine with or without food.

Different brands of this medicine may be taken differently. Swallow the capsule whole with a glass of water. Try to take it at the same time each day. The dose of this medicine will be decided by your doctor. Your doctor will advise you on the treatment timeframe depending on the type and severity of your condition.

Isotretinoin must be taken regularly for it to be effective. Continue taking this medicine even when you feel better. Do not stop taking it unless instructed by the doctor. What should I do if I have forgotten to take this medicine? Take the missed dose as soon as you remember. If it is almost time for your next dose, skip the missed dose and return to your normal dosing schedule.

DO NOT double a dose under any circumstances. If you often forget to take your medicine, let your doctor and pharmacist know. When should I not use this medicine? Alert your doctor if you have the following conditions: hypervitaminosis A very high level of vitamin A in your body excessively high levels of cholesterol and triglycerides fats in the blood liver disease as Isotretinoin may not be suitable for you.

Do not take this medicine if you are pregnant or planning to have a baby soon. If you become pregnant while being treated with this medicine, alert your doctor immediately.

Isotretinoin may cause harm to your unborn child. You must use proven birth control methods 1 month before starting, during the entire treatment, and for 1 month after stopping this medicine. Do not breastfeed while you are being treated with this medicine. Do not take Isotretinoin with tetracycline antibiotics or products containing vitamin A. What should I take note of while taking this medicine? Inform your doctor if you have the following conditions: dry eyes diabetes present condition of or risk factors for hypertriglyceridaemia high levels of fat in the blood e.

Children may be more sensitive to the side effects. This medicine is not indicated for the treatment of prepubertal acne pimples before puberty period. Do not switch brands unless instructed by your doctor. This is because different brands of Isotretinoin may have slightly different ways of working in your body.

Notify your doctor if you consume large amounts of alcohol or if you are a frequent drinker. Your skin may be more delicate while you are taking Isotretinoin. Avoid waxing hair removal or skin resurfacing procedures e. Do not donate blood while taking this medicine and for 1 month after treatment as this medicine may cause harm to the baby if a pregnant patient receives your blood.

Your acne may worsen during the first weeks of treatment. This is expected, your acne will eventually improve as treatment goes on. Do not share or give this medicine to anyone else. Why is it important to keep my appointments with the doctor? Keep your appointments with your doctor.

Your doctor needs to monitor your condition and check your response to the medication regularly. Routine pregnancy tests will be done before, during, and after treatment to know if this medicine is suited for you to take. Routine tests e. Regular monitoring of signs of depression, skin reactions, and changes in vision may also be needed.

Your doctor will advise you about how often you need to have these tests. What side effects could I experience? You may experience some problems with your eyesight, such as decreased ability to see at night.

Always keep your doctor updated on any changes in your eyesight. If affected, be cautious when driving and during any activity in which you need to see clearly. Isotretinoin may also make your skin more sensitive to sunlight. Apply sunscreen with at least SPF 15 and wear protective clothing when going outdoors and avoid prolonged exposure to sunlight and UV lamps. Other side effects include any of the following: headache, dry skin, eyes, lips and inside of the nose, eye irritation, back pain, muscle pain, joint pain, fragile skin, mild nosebleeds, decreased tolerance to contact lenses, and ringing in the ears.

Some side effects may need immediate medical help. Alert your doctor quickly if you experience any of the following: rashes with peeling of the skin or blistering of the lips, mouth or eyes accompanied by fever having thoughts of self-harm unusual changes in mood or behaviour being too depressed, agitated, or aggressive severe stomach pain, swelling of the stomach, nausea and vomiting, fever muscle weakness, trouble moving arms or legs, dark-coloured urine yellowing of the skin or eyes, abdominal pain, tiredness, swelling in the legs and ankles frequent or persistent sore throat with fever Inform your doctor if any of these side effects do not go away or are severe, or if you experience other side effects.

Can I take this with other medicines? Do not take Isotretinoin with the following medicines: certain antibiotics e. Avoid concomitant use with topical keratolytic or exfoliative anti-acne agents. Always notify your doctor and pharmacist if you are taking or using any other medicines, including herbal tonics such as traditional Chinese medicines, supplements and medicines that you buy without a prescription.

What special dietary instructions should I follow? Avoid alcohol. Avoid taking foods that are rich in vitamin A such as beef liver and cod liver oil.

How should I store this medicine? Store in a cool, dry place away from the reach of children. Protect from light. Medicines must not be used past the expiry date. This information is independently developed by MIMS based on isotretinoin - oral and is provided for your reference only. It may not contain all the available information you require and cannot substitute professional medical care, nor does it take into account all individual circumstances.

Although great effort has been made to ensure content accuracy, we shall not be held responsible or liable for any claims or damages arising from the use or misuse of the information contained herein, its contents or omissions, or otherwise. All rights reserved. Powered by MIMS. Other Known Brands. Acnotin Nimegen Oratane Roaccutane. Other Related Information. Isotretinoin - Topical.

Related Diseases. Acne Vulgaris Rosacea. Register or sign in to continue. Continue with Google. Sign Up. Already a member? Sign in.

Try to take it at the same time each day. The dose of this medicine will be decided by your doctor. Your doctor will advise you on the treatment timeframe. At Lazada Malaysia, you can find your outfit requirements for all your special occasions. Need the perfect gown for prom or a special dinner event find it. i) Symptomatic treatment of chronic stable angina pectoris in coronary artery disease adults with normal sinus rhythm and heart rate ≥ 70 bpm. Ivabradine is. Please refer to the Malaysia prescribing information. Generic Medicine Info. Indications and Dosage. Oral Acne. Adult: In severe cases such as nodular. Try to take it at the same time each day. The dose of this medicine will be decided by your doctor. Your doctor will advise you on the treatment timeframe. When should I not use this medicine? Register or sign in to continue. Skin and subcutaneous tissue disorders: Cheilitis, dermatitis, localised exfoliation, pruritus, rash erythematous, skin fragility, acute exacerbation of acne during initial treatment ; exfoliation, burning sensation or stinging of the skin, skin pain topical. Isotretinoin must be taken regularly for it to be effective. Although great effort has been made to ensure content accuracy, we shall not be held responsible or liable for any claims or damages arising from the use or misuse of the information contained herein, its contents or omissions, or otherwise. Routine tests e.

This information is not country-specific. Please refer to the Malaysia prescribing information. Indications and Dosage. Oral Acne Adult: In severe cases such as nodular or conglobate acne, or acne at risk of permanent scarring, which are resistant to standard therapy including systemic antibiotics and topical therapy: As conventional cap: Initially, 0. In patients who have severe intolerance to the recommended dose, treatment may be continued at a lower dose for a longer duration.

As lidose formulation: 0. As micronised formulation: 0. Doses may be adjusted according to patient response and tolerance. In case of relapse, may consider a 2nd course of treatment using the same daily dose and cumulative treatment dose; allow at least a 2-month drug-free period between treatments.

Dosage or treatment recommendations may vary among countries or individual products refer to specific product guidelines. Adult: For the treatment of mild to moderate cases with or without inflammation: As 0. Effect may be observed after weeks of treatment. Renal Impairment. Oral: Severe: As conventional cap: Initiate at a lower dose e. Hepatic Impairment. Hypervitaminosis A; hyperlipidaemia or excessively elevated blood lipid values. Hepatic impairment. Pregnancy and lactation. Concomitant use with tetracyclines and vitamin A including dietary supplements.

Special Precautions. Patient with diabetes mellitus, existing or at high risk of hypertriglyceridaemia e. Avoid blood donation during and for at least 1 month after treatment; aggressive chemical dermabrasion and cutaneous laser treatment during and for months after treatment and wax depilation during and for at least 6 months after treatment.

Avoid concurrent use with topical keratolytic or exfoliative anti-acne agents. Not indicated for prepubertal acne. Severe renal impairment. Some oral products or formulations are not interchangeable; refer to specific product guideline for further information.

Topical: Patient with history of photoallergy or photodermatitis, skin cancer personal or family history ; with concomitant rosacea or perioral dermatitis. Application to sensitive skin areas e. Delay therapy in patients with sunburn until resolved.

Avoid application to eczematous skin. Adverse Reactions. Significant: Hearing impairment, tinnitus; corneal opacities, dry eyes, keratitis, decreased tolerance to contact lenses, decreased night vision; decreased bone mineral density, osteoporosis, osteopenia, bone fractures, delay in healing of bone fractures, skeletal hyperostosis, premature epiphyseal closure, calcification of tendons and ligaments; photosensitivity, benign intracranial hypertension pseudotumour cerebri , hypersensitivity reactions e.

Irritation, redness, peeling, or discomfort topical. Blood and lymphatic system disorders: Anaemia, thrombocytopenia, thrombocytosis.

Eye disorders: Blepharitis, conjunctivitis, eye irritation. General disorders and administration site conditions: Application site erythema, pruritus or irritation, localised tenderness topical. Investigations: Increased RBC sedimentation rate.

Musculoskeletal and connective tissue disorders: Back pain particularly in adolescents. Nervous system disorders: Headache. Renal and urinary disorders: Haematuria, proteinuria. Reproductive system and breast disorders: Rarely, sexual dysfunction including erectile dysfunction and decreased libido. Respiratory, thoracic and mediastinal disorders: Nasopharyngitis, epistaxis, nasal dryness. Skin and subcutaneous tissue disorders: Cheilitis, dermatitis, localised exfoliation, pruritus, rash erythematous, skin fragility, acute exacerbation of acne during initial treatment ; exfoliation, burning sensation or stinging of the skin, skin pain topical.

Potentially Fatal: Severe skin reactions e. Stevens-Johnson syndrome, toxic epidermal necrolysis, erythema multiforme. Rarely, haemorrhagic pancreatitis, rhabdomyolysis, suicide attempts, suicide. Patient Counseling Information. This drug may reduce your ability to see at night, be cautious when driving or operating machinery during night-time.

Women of child-bearing potential must use proven contraceptive methods 1 or 2 methods 1 month before starting treatment, during the entire course, and 1 month after stopping treatment. Avoid or minimise prolonged exposure to sunlight or UV rays, if exposure cannot be avoided, use sunscreen with protection factor of at least SPF 15 or wear protective clothing.

Monitoring Parameters. Monitor LFTs and fasting lipid tests before treatment and weekly or biweekly until treatment response is established , CBC with differential and platelet count, sedimentation rate at baseline , blood glucose, creatine phosphokinase. Assess for signs and symptoms of depression, mood alteration, psychosis, aggression, severe skin reactions, and changes in vision.

Drug Interactions. May increase risk of local irritation with topical keratolytic or exfoliative anti-acne agents. Benzoyl peroxide may reduce the therapeutic efficacy of topical isotretinoin. Potentially Fatal: Concomitant use with tetracyclines resulted in benign intracranial hypertension pseudotumour cerebri.

May increase risk of additive toxic effects with vitamin A. Food Interaction. Description: Isotretinoin is a retinoid and the cis configuration of tretinoin. The exact mechanism for the treatment of acne has not yet been fully elucidated, but it has been noted to be associated with the inhibition of the sebaceous gland activity and follicular keratinisation.

It reduces sebum production reflecting a decrease in the size of sebaceous gland and inhibition of its differentiation. Topically, it stimulates epidermal mitosis, decreases intercellular cohesion in the stratum corneum, combats hyperkeratosis, aids in desquamation to prevent formation of lesions, and moderates an increase in production of less cohesive epidermal sebaceous cells to promote expulsion of comedones.

Pharmacokinetics: Absorption: Absorbed from the gastrointestinal tract oral ; minimal systemic absorption after topical application. Increased bioavailability with food.

Time to peak plasma concentration: Conventional cap: 5. Lidose formulation: 6. Micronised formulation: 5 hours fed ; 3.

Distribution: Crosses the placenta. Metabolism: Metabolised in the liver by CYP2B6, 2C8, 2C9, and 3A4 into 4-oxo-isotretinoin major active metabolite , retinoic acid tretinoin , and 4-oxo-retinoic acid 4-oxo-tretinoin. Undergoes enterohepatic recycling including its metabolites.

Excretion: Via urine and faeces in equal amounts. Lidose formulation: 18 hours isotretinoin ; 38 hours active metabolite. Micronised formulation: Approx 24 hours isotretinoin ; approx 38 hours active metabolite. Chemical Structure. PubChem Database. Protect from light. Topical gel: Keep away from fire, flame, or heat. Storage recommendations may vary among individual products.

Refer to specific product guideline. MIMS Class. Acne Treatment Preparations. ATC Classification. D10BA01 - isotretinoin ; Belongs to the class of systemic retinoid preparations used in the treatment of acne. D10AD04 - isotretinoin ; Belongs to the class of topical retinoid preparations used in the treatment of acne. Source: U. National Library of Medicine. MIMS Philippines. Isotretinoin Systemic. Lexicomp Online. Hudson, Ohio. Isotretinoin Topical. Bethesda, MD. Buckingham R ed. Martindale: The Complete Drug Reference [online].

Pharmaceutical Press. Isotretinoin 5 mg Capsules Ennogen Healthcare Limited. Isotretinoin Capsule Actavis Pharma, Inc.

Joint Formulary Committee.



Side effects of isotretinoin capsules - NHS.What should I do if I develop a skin rash while on isotretinoin treatment? - human

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